1. Age ≥ 18 years of age.
2. Have a Karnofsky performance status ≥ 70 (i.e., the patient must be able to care for him/herself with occasional help from others; refer to Appendix A).

        6. Have the following clinical laboratory values obtained within 14 days prior to
        registration:
          1. Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
          2. Platelets ≥ 100 x 109/L
          3. Hemoglobin (Hgb) ≥ 9.0 g/dL
          4. Total bilirubin: ≤ 1.5 x ULN
          5. ALT and AST ≤ 4.0 x ULN
          6. Creatinine ≤ 1.8 mg/dL
          7. Prothrombin time (PT) within 1.5x normal limits
          8. Activated partial thromboplastin time (aPPT) within 1.5x control
          9. International Normalized Ration (INR) less than or equal to 1.5x control
             7. Patient must have no active bleeding or pathological condition that carries a high
             risk of bleeding (e.g., coagulopathy)
             8. Available results from a contrast-enhanced, post-operative brain MRI that was
             completed within 72 hours after surgery documenting either:
        a. gross total resection consisting of no gadolinium enhancement; or b. near-total
        resection consisting of either ≤ 1 cm3 nodular (i.e. volumetric) enhancement or ≤ 100 mm2
        in cross sectional area (i.e. linear enhancement). Note: Patients who undergo either
        stereotactic biopsy or open biopsy for tissue diagnosis, or partial tumor resection, and
        who subsequently have a definitive surgical resection may still be eligible for inclusion,
        provided that randomization can occur within 16 weeks of the date of surgical resection. To
        be eligible, such patients must still meet postoperative imaging entry criteria as defined
        in item #8 above.
        9. Patients must have completed initial radiation therapy with TMZ (chemoradiation)
        according to established Stupp protocol (Stupp, 2005) for the treatment of their
        glioblastoma (i.e., completed 6-week course of RT and completed ≥ 75% of a course of
        concurrent TMZ chemotherapy).
        10. Patients must be randomized within 16 weeks of surgical resection of their newly
        diagnosed glioblastoma.
        11. No evidence of progressive disease at the post-chemoradiation timepoint based on
        changes in: neurologic exam, corticosteroid use or radiographic progression (i.e., baseline
        MRI evaluation). (See Section 14.5 for suspected pseudo-progression.)
        12. Participants of child-bearing potential (not surgically sterile or postmenopausal) must
        agree to use adequate contraceptive methods (e.g., hormonal or barrier method of birth
        control; abstinence) prior to study entry and have a negative pregnancy test prior to
        starting study treatment. Should a woman become pregnant or suspect she is pregnant while
        she or her partner is participating in this study, she should inform her treating physician
        immediately.
        13. Dexamethasone dose less than or equal to 4 mg daily at time of study enrollment. Every
        reasonable effort should be made to reduce the dose of corticosteroids to the absolute
        minimum dose required to control neurologic symptoms prior to receiving SurVaxM.
        14. Participant or legal representative must understand the investigational nature of this
        study and sign an Independent Ethics Committee/Institutional Review Board approved written
        informed consent form prior to receiving any study related procedure.
        Exclusion Criteria:
        Participants with any of the following will be excluded from this study:
          1. Recurrent or progressive glioblastoma.
          2. Gliosarcoma, anaplastic astrocytoma, oligodendroglioma, ependymoma, low grade glioma
             or any histology other than glioblastoma.
          3. Multicentric glioblastoma or glioblastoma involving the brainstem or cerebellum, or
             leptomeningeal or spinal extension present at diagnosis.
          4. Residual contrast enhancement > 1 cm3 on post-operative scan obtained within 72 hours
             of surgery.
          5. Absence of MRI obtained within 72 hours of craniotomy documenting
             ≤ 1 cm3 contrast-enhancing tumor.
          6. Patients who elect to have Optune therapy (Tumor Treating Fields) are not eligible to
             participate in this trial.
          7. Patient has had non-standard radiation therapy for glioblastoma (i.e., whole brain
             radiation therapy, gamma knife or LINAC stereotactic radiosurgery).
          8. Prior or concurrent immunotherapy for brain tumor, including immune checkpoint
             inhibitors (pembrolizumab, nivolumab or ipilimumab) or other cancer vaccine therapy.
          9. Prior or concurrent treatment with bevacizumab.
         10. Patients with serious concurrent infection or medical illness, which in the treating
             physician's opinion would jeopardize the ability of the patient to receive the
             treatment outlined in this protocol with reasonable safety.
         11. History of tuberculosis or other granulomatous disease.
         12. Patient is pregnant or breast-feeding.
         13. Patient has received any other chemotherapeutic agent or investigational drug in
             addition to standard of care radiation therapy with concomitant temozolomide
             (chemoradiation per Stupp protocol).
         14. Patient with concurrent or prior malignancy is ineligible unless he or she has had
             curatively treated carcinoma-in-situ or basal cell carcinoma of the skin.
         15. Patients who have had repeat craniotomy for tumor therapy after receiving RT and TMZ
             treatment (i.e., chemoradiation).
         16. Patients who have had surgical implantation of carmustine (Gliadel) wafers are not
             eligible to participate in this study.
         17. Known history of systemic autoimmune disorder.
         18. Known human immunodeficiency virus (HIV) positivity or acquired immunodeficiency
             syndrome (AIDS) related illness or other serious medical illness.
         19. Patient has a contraindication to MRI scans or to gadolinium contrast agent.
         20. Patient has a contraindication to temozolomide.
         21. Patient is unwilling or unable to follow protocol requirements.
         22. Patient has received any other investigational treatment for the glioblastoma.
         23. Any condition which in the Investigator's opinion makes the candidate unsuitable to
             receive the study drug or protocol procedures.